Vitaran II 2x2ml

VITARAN II represents a modern, biologically-oriented approach to skin revitalization — aligned with the principles of regenerative aesthetics. As a polynucleotide (PN) injectable, VITARAN II is formulated with highly purified, sterilized fragments of salmon/trout DNA at a concentration of 2% (20 mg/ml).  The polynucleotides in VITARAN II serve as bio-stimulators: once injected intradermally by trained aesthetic practitioners, they exert multiple effects at the cellular level.

Mechanism of Action and Biological Effects
Upon administration, PN fragments interact with dermal fibroblasts, promoting their activation and stimulating the synthesis of new extracellular matrix components — notably collagen (types I and III) and elastin.  This fibroblast activation contributes to increased dermal density, improved skin elasticity and firmness, and a more resilient skin structural network. In addition, VITARAN II promotes restoration of the skin barrier, enhances moisture retention, and supports tissue regeneration — restoring skin health from within. 

Beyond structural remodeling, VITARAN II exhibits anti-inflammatory and antioxidant properties, which help reduce redness, counteract oxidative stress and free-radical damage, and support healthier skin renewal.  These combined actions — structural rejuvenation, barrier repair, hydration boost, and anti-oxidative support — make VITARAN II particularly effective for addressing early to moderate signs of intrinsic and extrinsic aging, as well as skin compromised by environmental stressors.

Clinical Indications and Use Cases
As a non-volumizing, bioactive injectable, VITARAN II is optimally indicated for:

• Skin laxity, loss of firmness, and decreased elasticity

• Fine lines, wrinkles, and superficial wrinkles (especially early signs of aging)

• Loss of dermal density and thinning skin (e.g., due to age or photo-aging)

• Dehydrated, dull, or uneven skin tone and texture

• Post-procedure skin recovery (e.g., after energy-based device treatments, microneedling, peels)

• Areas with superficial scarring, uneven texture, or sun-damage

• Preventive anti-aging maintenance for clients seeking improved skin quality without volumizing effect

Given its versatility, VITARAN II can be integrated into diverse aesthetic protocols — standalone intradermal PN therapy, or as part of a combined treatment plan (e.g., followed by skin boosters, HA-based fillers, microneedling, PRP, or chemical peels), depending on the clinic’s approach and patient’s skin condition. Several distributors highlight that VITARAN II can be used alongside other injectables — provided not administered at the exact same anatomical point — allowing practitioners to customize multi-modal regenerative treatments. 

Administration and Treatment Protocol
For optimal results, aesthetic practitioners typically administer VITARAN II intradermally, using microdroplet, linear threading, or mesotherapy techniques, depending on treatment area and desired effect. 

Protocol recommendations from distributors vary: many recommend a course of 2–4 sessions spaced 2–4 weeks apart, followed by maintenance treatments every 6–12 months, depending on patient skin condition and response.  Clinical improvements — such as increased firmness, improved elasticity, better skin texture, and enhanced hydration — are commonly observed gradually over weeks, with cumulative benefits after successive sessions.

Safety and Regulatory Compliance
VITARAN II is CE-marked, indicating conformity with EU regulatory and safety standards for medical devices / injectables.  It is presented as a sterile, apyrogenic injectable solution, intended for professional use only. Most distributors emphasize that administration should only occur by trained, qualified aesthetic practitioners. 

Because the formulation does not rely on cross-linking agents or volumizing fillers, but on biologically active PN fragments, the risk of overcorrection, lumps or nodules is minimized — making it a safe choice for clients seeking subtle, natural-looking rejuvenation, improved skin quality, and long-term dermal health.

Why VITARAN II Makes Sense for a Clinic Portfolio
For a medical aesthetic pharmacy like Skin On You Ltd supplying to skin therapists, aesthetic practitioners, and clinic owners, VITARAN II represents a valuable addition to non-surgical, regenerative treatment offerings. It enables clinics to offer a biologically-driven skin revitalization solution that addresses not only superficial signs of aging, but deeper dermal structure and skin health — appealing to patients seeking longevity, improved skin quality, and preventive dermatology.

The 2 × 2 ml packaging provides flexibility: enough product for multiple treatment sessions or for treating larger or multiple anatomical regions (e.g., combining face + neck, or face + décolletage + hands), which is cost-effective for clinics with busy patient flow.

By integrating VITARAN II into treatment protocols — alone or in combination with other modalities (HA skin boosters, microneedling, PRP, energy-based devices, etc.) — clinics can deliver comprehensive regenerative aesthetic solutions, enhancing patient satisfaction and retention, while expanding treatment variety.

Treatment Areas

• Face (full-face rejuvenation)

• Neck 

• Décolleté / chest area 

• Hands (for photo-aging, loss of elasticity) 

• Body (e.g., abdomen, arms, other areas as indicated) — for skin laxity or crepey skin on larger body zones. 

Usage

• Administered intradermally by qualified aesthetic practitioners using microdroplet, linear threading or mesotherapy techniques. Typical protocol: 2–4 treatment sessions spaced 2–4 weeks apart, for initial course. Maintenance treatments: every 6–12 months, depending on patient’s skin condition and response. 

• Can be combined with other aesthetic treatments (HA-based skin boosters, microneedling, PRP, chemical peels, etc.), provided injections are not in the exact same anatomical points. 

Ingredient List

• Active Ingredient: Polynucleotide Sodium, 20 mg/ml (PN 2%) — highly purified salmon/trout DNA fragments. 

• Solvent: Sterile buffered saline (or equivalent biocompatible vehicle) — to ensure sterility and biocompatibility (standard for PN injectables).

• Pack includes sterile syringes and sterile 33 G (or 34 G) needles depending on supplier. 

Main ingredient description:

• Polynucleotide Sodium (PN 2%): Biologically derived DNA fragments from salmon/trout, selected for their high compatibility with human skin and low immunogenicity. These PN fragments act as signalling molecules at the dermal level, promoting fibroblast activation, increasing dermal matrix synthesis (collagen & elastin), improving skin barrier function, stimulating cellular repair and regeneration, and enhancing tissue hydration and elasticity.

Product Dimensions / Size

• Pack: 2 pre-filled sterile syringes × 2 ml each (total 4 ml).

• Each syringe supplied with a sterile needle (33G or 34G depending on distributor) for intradermal injection.

Product Duration (Longevity of Results)

• Clinical benefit duration varies depending on skin condition, patient lifestyle, and maintenance protocol. Many sources indicate visible improvements lasting 6–12 months with proper maintenance.

• For deeper structural improvements (dermal density, elasticity, skin barrier), result persistence is longer and cumulative across repeated sessions — making VITARAN II suitable for long-term skin health and maintenance programs.

  5 Popular Questions & Answers:

  1. What is the difference between VITARAN II and a traditional HA-based skin booster or filler?
  VITARAN II is a polynucleotide-based bio-revitalizer — it does not volumize or add structural volume. Instead, it works at a cellular level to stimulate fibroblasts, increasing new collagen and elastin synthesis, improving dermal density, elasticity, texture, hydration, and skin barrier function. In contrast, HA-based boosters or fillers primarily deliver volume and hydration or immediate plumping. VITARAN II is ideal when the clinical goal is skin quality improvement, long-term remodeling, and regeneration, rather than volumizing.

  2. Which areas can be treated with VITARAN II?
  VITARAN II is suitable for larger treatment areas and commonly used on face, neck, décolleté, hands, and even body zones such as abdomen or arms. Use cases include improving skin laxity, fine lines, uneven texture, dehydration, early signs of ageing, or post-procedure skin support.

  3. How many treatment sessions are needed, and how long do results last?
  Standard protocol suggests 2–4 sessions spaced 2–4 weeks apart for the initial course, performed by trained practitioners. Maintenance may be done every 6–12 months depending on skin condition and client response. Results like improved elasticity, hydration, and skin quality typically persist for 6–12 months, with cumulative benefits over repeated sessions.

  4. Can VITARAN II be combined with other aesthetic treatments (e.g., HA boosters, microneedling, PRP)?
  Yes. Because VITARAN II acts as a bio-revitalizer (not a volumizer), it can be integrated into multi-modal protocols — for example, combined with HA skin boosters, PRP, microneedling, or even chemical peels — as long as injections are not done in the exact same anatomical point at the same time. This synergistic approach can enhance overall skin rejuvenation, collagen-stimulation, and long-term dermal health.

  5. What are the main contraindications or safety considerations for VITARAN II?
  As with all injectable polynucleotide products, VITARAN II should be administered only by qualified, trained aesthetic practitioners. Contraindications may include fish/salmon DNA allergy, active skin infections, uncontrolled autoimmune disease, pregnancy or breastfeeding, or patients under 18. Because the product uses DNA fragments, practitioners should conduct thorough patient history and allergy screening before treatment. Strict aseptic technique during injection is mandatory.